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Background
Eczema is a skin condition which affects up to 10% to 20% of people worldwide. Previous literature finds that low vitamin D levels may be a risk factor for eczema, but the association is not clear.
Methods
We used the cross‐sectional data from U.S. National Health and Nutrition Examination Survey 2005‐2006. Adults were defined as 20 years and older. The association between eczema and...
Background
Histamine is an important immunomodulator influencing both the innate and adaptive immune system. Certain host cells express the histidine decarboxylase enzyme (HDC), which is responsible for catalysing the decarboxylation of histidine to histamine. We and others have shown that bacterial strains can also express HDC and secrete histamine; however, the influence of bacterial‐derived histamine...
Background
Peanuts are most responsible for food‐induced anaphylaxis in adults in developed countries. An effective and safe immunotherapy is urgently needed. The aim of this study was to investigate the immunogenicity, allergenicity, and immunotherapeutic efficacy of a well‐characterized chemically modified peanut extract (MPE) adsorbed to Al(OH)3.
Methods
Peanut extract (PE) was modified by reduction...
Background
Research based on cluster analyses led to the identification of particular phenotypes confirming phenotypic heterogeneity of asthma. The long‐term clinical course of asthma phenotypes defined by clustering analysis remains unknown, although it is a key aspect to underpin their clinical relevance. We aimed to estimate risk of poor asthma events between asthma clusters identified 20 years...
Introduction
The objective of this study was to analyze mortality, possible predictors of long‐term survival, and health‐related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample.
Methods
Longitudinal study in patients diagnosed with CHP during 2004‐2013, followed for at least 1 year. Patients remaining alive and consenting to participate had a follow‐up visit...
Background
While most studies focus on pro‐allergic cytokines, the protective role of immunosuppressive cytokines in allergic inflammation is not well elucidated. This study was to explore a novel anti‐inflammatory role and cellular/molecular mechanism of IL‐27 in allergic inflammation.
Methods
A murine model of experimental allergic conjunctivitis (EAC) was induced in BALB/c, C57BL/6 or IL‐27Rα‐deficient...
Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion animals to those in people. With few exceptions, the situation...
Peanut is one of the most common food triggers of fatal anaphylaxis worldwide although peanut allergy affects only 1%‐2% of the general population. Peanuts are the source of highly potent allergenic proteins. It is emerging that the allergenicity of certain proteins is linked to their biological function. Peanut is an unusual crop in that it flowers aboveground but produces its seed‐containing pods...
Background
We previously showed that patients with severe allergic asthma have high numbers of circulating ILC2s expressing CCR10.
Method
Herein, CCR10+ ILC2s were further analyzed in the blood of healthy individuals or patients with allergic and non−allergic asthma. Characteristics of human CCR10+ and CCR10− ILC2s were assessed by flow cytometry as well as single‐cell multiplex RT‐qPCR. The role...
Background
A special regulatory role for prostaglandin E2 (PGE2) has been postulated in nonsteroidal anti‐inflammatory drug (NSAID)–exacerbated respiratory disease (NERD).
Objective
To investigate the effect of systemic aspirin (acetylsalicylic acid) administration on airway PGE2 biosynthesis in induced sputum supernatant (ISS) among subjects with NERD or aspirin‐tolerant asthma with chronic rhinosinusitis...
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